How Long Does Malarone Stay in Your System?

Traveling to tropical regions often requires taking precautions against malaria, and Malarone is a top choice for many. But how long does it remain in your system after the last dose?

How Long Does Malarone Stay in Your System?

Malarone, an antimalarial medication, can be detected in the blood for up to 7 days after the last dose. However, its active effects in terms of malaria prevention can last for up to a month. 

The exact duration can vary based on individual factors like age, metabolism, dosage, and frequency of use.

What is Malarone?

Malarone is a combination of two drugs: atovaquone and proguanil.

Together, they work to kill the malaria parasite in the liver and bloodstream.

It’s often prescribed to travelers heading to areas where malaria is prevalent.

Factors Influencing Malarone’s Duration in the System

Several factors can influence the duration:

  • Age: Metabolism rates differ with age, potentially affecting how long the drug remains in the system.
  • Metabolism: Individuals with faster metabolic rates might process the drug quicker.
  • Dosage: The amount taken can influence the duration it stays in the system.
  • Frequency of use: Regular use can lead to the drug accumulating in the system.

Side Effects and Precautions

While Malarone is generally well-tolerated, some individuals might experience side effects like nausea, headache, or stomach pain. It’s essential to:

  • Follow the recommended dosage: Overdosing can lead to severe side effects.
  • Consult a doctor: If side effects persist or if there’s a suspected overdose.


Typically, after the last dose, Malarone can be detected in the blood for up to 7 days. However, its active effects, in terms of malaria prevention, can last for up to a month.

Understanding the duration of medications like Malarone in the system is crucial for both effective malaria prevention and ensuring no drug interactions with other medications.

Always consult with a healthcare professional before starting or stopping any medication.

Meet Assil LAB, a passionate writer and contributor at Veganoga. Specializing in the vegan lifestyle and cooking, Assil shares insightful articles that inspire readers to embrace plant-based living. Discover her engaging content and unique vegan recipes today.